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Interestingly, when we treated the samples with the deubiquitinase USP7, the higher molecule species were only partially reduced, indicating the presence of a mixture of both polyubiquitinated populations and membrane protein aggregates (Supplemental Figure 3)

In one clinical trial assessing the efficacy of phentermine and vitamin B-12 for weight loss, vitamin B-12 injections were used as the sole ingredient of 1,000 mg per week